INTRODUCTION

Traumatic pancreatic injuries are rare, accounting for fewer than 1% of all trauma patients and 3–12% of abdominal trauma patients [1-4]. The pancreas is located in the retroperitoneum and is surrounded by important organs. Therefore, pancreatic injuries are often accompanied by injuries of the surrounding organs. These factors delay the diagnosis of pancreatic injuries and make them difficult to manage. For these reasons, pancreatic injuries have high morbidity and mortality rates [5,6].

The treatment of these pancreatic injuries requires a multidisciplinary approach and tends to use a variety of methods, including endoscopy and interventions, with both non-surgical and surgical treatment as deemed appropriate [7]. The aim of this study was to evaluate and report our experiences with the management of pancreatic injuries.

METHODS

This study surveyed patients who presented to a single regional trauma center for trauma from January 2014 to December 2020. We excluded patients younger than 16 years of age. Data related to patients’ demographic characteristics and mechanism of injury were abstracted from the Korea Trauma Database. Patients’ medical records were retrospectively reviewed and the following data were evaluated: initial vital signs, laboratory findings, grade of the pancreatic injury, Injury Severity Score (ISS), type of management, and hospital course. The grade of pancreatic injury was classified using the American Association for the Surgery for Trauma (AAST) system.

Quantitative variables were expressed as mean±standard deviation. A univariate analysis was performed using the Student t-test for continuous variables and the chisquare test for categorical variables. The threshold for statistical significance was set at p<0.05. All statistical analyses were performed using SPSS version 20.0 (IBM Corp., Armonk, NY, USA).

RESULTS

In total, 45 patients were evaluated. Twenty-eight patients (62.2%) underwent laparotomy and 17 (37.8%) received nonoperative management (NOM). The demographic and clinical characteristics of the two groups were compared. Most of the patients had blunt injuries (88.9%) and were injured in a motor vehicle crash (57.8%). According to the AAST grading system, 21 patients (46.6%) had pancreatic injuries of grade 3 or higher. The NOM group contained patients with grade 1–3 injuries, and no patients with grade 4, 5 injuries received NOM. Correspondingly, no grade 1 patients received operative management. The patients who received operative management had poorer Glasgow Coma Scale scores, initial hemoglobin levels, and ISS, and their mortality was high. The overall mortality rate was 24.4% (n=11) and only one patient died after NOM, due to a severe traumatic brain injury (Table 1).

Injuries associated with the abdomen (Abbreviated Injury Scale ≥3) were present in 93% of cases, with the highest frequency found for solid organ, hollow viscus, and vascular injuries. A combined injury was defined as having two or more abdominal injuries. Vascular injuries were significantly more common in patients who died than in survivors (p=0.003) (Table 2).

The treatment process of surgical patients was investigated. Twenty-two of the surgical patients underwent emergency surgery and six underwent delayed surgery. Damage control surgery was performed in 14 of the patients who underwent emergency surgery. A drainage procedure was performed in 12 patients (42.9%), and pancreatectomy was performed in 16 patients (57.1%): distal pancreatectomy (DP), n=8; DP with spleen preservation, n=5; pancreaticoduodenectomy, n=2; and total pancreatectomy, n=1. There were four patients with grade 4 and the following surgeries were performed: drainage procedure, n=2; DP with spleen preservation, n=1; pancreaticoduodenectomy, n=1. Three of these patients died from disseminated intravascular coagulation due to damage to the organs surrounding the pancreas. One patient who underwent DP survived. There were two patients with AAST grade 5. They underwent pancreaticoduodenectomy and total pancreatectomy but both died. Two patients died after surgery due to necrotizing pancreatitis and anastomosis leakage, respectively.

Complications occurred in nine cases. There were five cases of fluid collection, two cases of pancreatic fistula, one case of anastomosis leakage, and one case of necrotizing pancreatitis (Table 3).

Of the 17 patients who received NOM, 12 were observed without any other procedure. Five patients underwent endoscopic retrograde cholangiopancreatography (ERCP), three of whom underwent pancreatic duct stent insertion. One patient who underwent ERCP was grade 2 and the other four were grade 3. In the NOM patients, five complications occurred, including four pancreatic pseudocysts and one case of pancreatitis (Table 4).

DISCUSSION

Pancreatic injuries are uncommon, but can be fatal. Although a treatment protocol for pancreatic injuries has been established to some extent, accompanying injuries are common, and the appropriate treatment therefore varies considerably from case to case.

In this study, most injuries resulted from blunt trauma, and traffic accidents were the most common cause. This is similar to the results of previous studies in Korea, Europe, and Australia [8-10]. In contrast, the United States and South Africa have a high rate of penetrating wounds [1,11,12].

The management of pancreatic injuries has not been established with certainty. In most cases, NOM is attempted for low-grade injuries with intact ducts. However, no consensus yet exists regarding the treatment strategy for severe injuries (AAST grades 4, 5). In recent years, there have been many cases of successful NOM involving embolization or endoscopic procedures, as well as surgical treatment [13].

At our center, 28 patients underwent surgery. The patients who underwent surgery had significantly lower initial Hb levels, lower GCS scores, and higher ISS. The AAST grade of their injuries was 2 or higher. Since most of the injuries were caused by blunt trauma, there were many accompanying injuries to surrounding organs. For AAST grade 2 injuries, bleeding control and drainage were most commonly performed (in one case, vessel reconstruction was performed with distal pancreatectomy due to multiple lacerations of the proximal superior mesenteric vein), and distal pancreatectomy was performed for AAST grade 3 cases. Two of the patients who underwent distal pancreatectomy had complications and underwent ERCP.

According to Jurkovich [14], the most difficult injuries to manage—and those for which the least consensus exists—are AAST grade 4, 5 injuries. In this study, surgery was performed for all AAST grade 4, 5 injuries. Five patients died after surgery due to disseminated intravascular coagulation, necrotizing pancreatitis and anastomosis leakage.

Six patients underwent delayed surgery due to misdiagnosis. In blunt abdominal injuries, the affected area is extensive and there are often accompanying injuries; therefore, symptoms due to pancreatic injuries appear late. The pancreas is located in the retroperitoneum, and the symptoms felt by the patient are ambiguous and easily underestimated by medical staff [15,16]. Computed tomography (CT) has recently become the standard imaging technique for diagnosing trauma patients, but in some cases, pancreatic damage cannot be detected on the initial CT scan [17,18]. A delayed diagnosis can lead to serious complications such as intra-abdominal bleeding and pancreatic fistula, which can even progress to death [19]. If pancreatic damage is suspected due to the injury mechanism or if unspecified symptoms persist, a secondary CT scan can be performed within 8 to 12 hours to detect pancreatic transection and peripancreatic fluid [14].

NOM was performed in 17 patients, who had relatively low AAST grades (grades 1, 2, and 3). Four patients had pancreatic duct injury (AAST grades 3), and all of them underwent ERCP. Among them, three patients were treated with stent insertion. In patients with pancreatic duct injury, successful NOM was achieved by combining ERCP, endoscopic retrograde pancreatic drainage, and percutaneous drainage. There is an increasing trend towards NOM for lower-grade injuries [20]. A recent US study reported that from 1998 to 2009, the proportion of non-surgically managed patients increased from 56.7% to 59.1% (p<0.01) and the mortality rate decreased from 9.7% to 8.6% (p<0.0001) [13]. The purpose of ERCP is to confirm the diagnosis of pancreatic duct injury and to place a bridge prosthesis in the area of damage [21]. Rogers et al. [4] showed promising results for endoscopic papillary pancreatic duct stenting, but concerns about long-term ductal structure remain.

Fourteen (31%) pancreas-specific complications occurred. Among them, two patients with anastomosis leakage and necrotizing pancreatitis, respectively, died. The complications of the remaining patients were managed without surgery. According to the literature, complications of pancreatic injuries are reported to occur in 12–34% of cases, including abscesses (6–32%), fistula (10–32%), pancreatic pseudocyst (5–30%), and pancreatitis (10–15%) [22,23].

The mortality rate was 24.4%: 35.7% in the operation group and 5.9% in the NOM group. The only cause of death in the NOM group was severe traumatic brain injury. According to the literature, the mortality rate of pancreatic injuries is high, with reported rates ranging from as low as 7.1% to 46.0%. Age, male sex, blunt trauma, hemodynamic compromise, high-grade injuries, and associated vascular injuries have been identified as significant prognostic factors associated with mortality [2,9,10,24].

There are some limitations of this study. First, it was a single-center study that included a small number of patients. Since a randomized controlled study was impossible due to the characteristics of trauma patients, a retrospective study was conducted. Patients with pancreatic injuries are usually polytrauma patients. Therefore, mortality involves various factors.

CONCLUSION

For traumatic pancreatic injuries, an appropriate treatment method should be considered after evaluation of the accompanying injury and the patient’s hemodynamic status. Patients with severe pancreatic injuries requiring surgery have a high mortality rate. NOM can be performed without mortality in appropriately selected cases.

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References

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