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Original Article
Comparative Analysis between Spinning and Other Causes in Exercise-Induced Rhabdomyolysis
Do Won Shim, M.D.1, Sung Youl Hyun, M.D.2, Jae Hyug Woo, M.D.1, Jae Ho Jang, M.D.1, Jae Yeon Choi, M.D.1
Journal of Trauma and Injury 2018;31(3):159-165.
Published online: December 31, 2018
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1Department of Emergency Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea

2Department of Traumatology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea

Correspondence to: Sung Youl Hyun, M.D., Department of Traumatology, Gachon University Gil Medical Center, 21 Namdong-daero 774beon-gil, Namdong-gu, Incheon 21565, Korea, Tel: +82-32-460-3015, Fax: +82-32-460-3019, E-mail:
• Received: August 30, 2018   • Revised: September 29, 2018   • Accepted: October 1, 2018

Copyright © 2018 The Korean Society of Trauma

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • Purpose
    Spinning-induced rhabdomyolysis (SIR) has been increasing in recent years and accounts for a large proportion of exercise-induced rhabdomyolysis (EIR). The purpose of this study was to compare the clinical features between SIR and non-spinning exercise-induced rhabdomyolysis (NSIR), and to analyze each of these clinical features.
  • Methods
    A retrospective chart review was conducted on patients treated due to EIR from January 2006 to March 2018. Patients were divided into the SIR and NSIR groups, and their clinical factors, outcome, and blood chemistries were compared and analyzed.
  • Results
    Sixty-two patients were enrolled in this study, with 23 (37.1%) and 39 (62.9%) patients categorized in the SIR and NSIR groups, respectively. The SIR group were mostly women (78.3% vs. 38.5%, p=0.002), more f requent EIR occurrence in the first exercise class (60.9% vs. 15.4%, p=0.001), and had most complaints of thigh pain (91.3% vs. 43.6%, p=0.001). The SIR group had a higher incidence rate despite its shorter exercise duration (90.5% vs. 62.9%, p=0.024), longer hospital stay (6.0 [4.5–7.0] vs. 5.0 [3.5–6.0] days, p=0.080), and higher rate of peak CPK (15,000 U/L or higher) (91.3% vs. 74.4%, p=0.182) compared to the NSIR group.
  • Conclusions
    SIR occurs at a higher rate during the first exercise class in women compared to NSIR, and the incidence rate is higher in SIR than in NSIR despite its shorter exercise duration (less than 60 minutes). It is necessary to recognize these risks during spinning exercises and to perform these exercises sequentially and systematically.
Rhabdomyolysis is a clinical and biochemical syndrome characterized by skeletal muscle necrosis and leakage of intracellular muscle constituents into the circulation [1]. Common initial symptoms of rhabdomyolysis involve generalized myalgia with or without muscle weakness and dark-urine secondary to myoglobin [2]. Multiple etiologies of rhabdomyolysis include burns, crush trauma, muscle compression, muscle overexertion, infections, toxins, drugs, inherited disorders of muscle metabolism, and so on [3]. Among the various etiologies, exercise-induced rhabdomyolysis (EIR) occurs when the energy supplied to the muscle is insufficient [4].
Spinning-induced rhabdomyolysis (SIR) has been increasing in recent years, accounting for a large proportion of EIR cases [5]. Spinning is an indoor cycling exercise that has become popular over the past few years. It is a cardiovascular exercise using stationary cycles with rhythmical music. Although some recent studies have reported on SIR cases [2,57], the comparison of the SIR with non-spinning exercise-induced rhabdomyolysis (NSIR) has rarely been studied [8]. Thus, this study aimed to compare the clinical features between SIR and NSIR by analyzing each of their clinical factors, outcomes, and blood chemistries.
Study design and population
From January 2006 to March 2018, we retrospectively reviewed the records of patients with EIR who were treated in our medical center. The medical center has about 90,000 to 100,000 and 1,100,000 patients visiting the emergency and outpatient departments annually.
Serum creatine phosphokinase (CPK) value of five times higher than the upper limit of the normal or muscle uptake obtained via whole body bone scan test was a diagnostic method for rhabdomyolysis in previous large studies [810]. EIR was defined as a rhabdomyolysis due to marked exertion by trained or untrained people [6]. In this study, we enrolled EIR patients whose serum CPK level was 1,500 U/L or higher. The patients with EIR was divided into the following two groups according to the exercises performed: SIR group for spinning and NSIR group for other exercises.
The diagnosis of acute kidney injury (AKI) was based on the risk, injury, failure, loss of kidney function, and end-stage kidney disease (RIFLE), Acute Kidney Injury Network (AKIN), or Kidney Disease: Improving Global Outcomes criteria [11].
We compared the patients’ sex, age, body mass index (BMI), first exercise class ratio, exercise duration, previous experience, medical history, initial symptom, chief complaint, and location of initial visit as clinical variables between the patient groups. Moreover, we investigated the length of hospital stay, time from activity to peak CPK, bone scan uptake, and complications. We compared the blood chemistries, such as CPK, aspartate transaminase (AST), alanine transaminase (ALT), creatine kinase-muscle/ brain (CK-MB), myoglobin, liver function test, electrolyte, blood urea nitrogen (BUN), creatinine (Cr), osmolality, uric acid, lactate, pH, anion gap between the groups.
Statistical analysis
The collected data were analyzed using SPSS Statistics version 22.0 (IBM Corp., Armonk, NY, USA). The chisquare test was used when the dependent variable was a categorical variable. Student’s t-test was used when the dependent variable was continuous and followed a normal distribution, whereas Mann-Whitney test was used when the dependent variable was not. All the statistical analyses were two-sided tests, and a p-value less than 0.05 was considered statistically significant.
During the 14-year study period, 70 patients with EIR were included, but we excluded two patients with missing data and six patients with a CPK level of less than 1,500 U/L. Sixty-two patients were finally enrolled. Among the 62 patients, EIR of the 23 (37.1%) patients was caused by a spinning exercise, whereas that of the 39 (62.9%) patients was caused by other types of exercise (Fig. 1). EIR occurred in various types of exercise, including spinning (n=23), weight training (n=13), squatting (n=8), cycling (n=3), CrossFit (n=3), swimming (n=3), walking (n=2), push up (n=2), running (n=1), boxing (n=1), climbing (n=1), Pilates (n=1), and playing soccer (n=1).
The proportion of the female patients was significantly higher in the SIR group (78.3% vs. 38.5%, p=0.002) (Table 1). The median age was not significantly different between the two groups (28.0 [22.0–30.0] vs. 26.0 [22.0–30.5], p=0.907). BMI was higher in the SIR group than in the NSIR group. The first exercise class ratio was significantly higher in the SIR group than in the NSIR group (60.9% vs. 15.4%, p=0.001). Most patients with SIR had bilateral thigh pain (91.3% vs. 43.6%, p=0.001), whereas those with NSIR had pain involving various muscle groups, including chest, abdomen, back, and arms. The rate of rhabdomyolysis was significantly higher in the SIR group than in the NSIR group despite the shorter exercise duration (less than 60 minutes) (90.5% vs. 62.9%, p=0.024) (Fig. 2). The admission rate (91.3% vs. 84.6%, p=0.523) and the length of hospital stay (6.0 [4.5–7.0] vs. 5.0 [3.5–6.0] days, p=0.08) were higher in the SIR group. The whole-body bone scan was performed in seven and 16 patients in the SIR and NSIR groups, respectively, and bilateral thigh uptake was confirmed in seven and 13 patients, respectively.
The SIR group had more patients with a peak CPK level of 15,000 U/L or higher compared to the NSIR group (91.3% vs. 74.4%, p=0.182) (Fig. 2). The CPK value of 15,000 U/L or higher was measured at 15,000 U/L and was marked as 15,000 U/L. The laboratory test results of both the SIR and NSIR groups were as follows (Table 2): initial CPK (15,000.0 [15,000.0–15,000.0] vs. 15,000.0 [14,839.5–15,000.0] U/L, p=0.549), peak CPK (15,000.0 [15,000.0–15,000.0] vs. 15,000.0 [14,839.5–15,000.0] U/L, p=0.359), AST (869.0 [632.5–1,250.5] vs. 482.0 [217.5–1,333.5] U/L, p=0.117), and ALT (298.0 [154.0–378.0] vs. 180.0 [120.5–338.0] U/L, p=0.153). Each value showed a higher tendency in the SIR group. Initial CK-MB level was significantly higher in the SIR group (88.95 [25.30–103.60] vs. 25.65 [10.70–50.85] ng/mL, p=0.012). However, BUN (10.60 [8.00–12.15] vs. 15.30 [11.80–18.55] mg/dL, p<0.001), Cr (0.60 [0.50–0.60] vs. 0.80 [0.60–0.92] mg/dL, p=0.001), and initial pH (7.39 [7.37–7.40] vs. 7.42 [7.40–7.43], p=0.042) were significantly lower in the SIR group.
In this study, we compared the clinical features between patients with SIR and those with NSIR. We found that SIR occurs at a higher rate during the first exercise class in women compared to NSIR, and the incidence rate is higher in SIR than in NSIR despite the short exercise duration, higher peak CPK, and longer hospital stay.
In a previous analysis, patients at risk of developing EIR tend to be younger and are usually male [12]. Moreover, it has been reported that men are vulnerable to EIR because estrogen plays a protective role [13]. In addition, studies have shown that high BMI is associated with the development of rhabdomyolysis [14]. In this study, the mean age of both the SIR and NSIR groups was less than 30 years, and the age was not significantly different from the previous study. The SIR group had a higher proportion of female patients and a higher BMI than the NSIR group, which might be possibly due to the following reasons: relatively overweight women are performing more spinning exercises than other exercises; they had a nutritional imbalance, or the majority of patients have never exercised before [7].
Spinning class participants adopt different positions and vary the resistance on the cycle, thus simulating climbing hills or cycling on flat roads. This requires repetitive use of the large muscle groups of the bilateral hip and legs, mainly the gluteus maximus and quadriceps muscles [15]. In this study, the majority of patients with SIR complained of thigh pain for the abovementioned reasons, and all patients who underwent a bone scan had thigh uptake.
EIR is characterized by the breakdown and necrosis of striated skeletal muscles after a physical activity. This muscle injury leads to the leakage of muscle cell contents, including electrolytes, myoglobin, and other sarcoplasmic proteins (e.g., creatinine phosphokinase, aldolase, lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase) into the circulation [16]. In particular, serum CPK begins to increase 2–12 hours after the adjustment period and peaks within 24–72 hours. CPK has a half-life of 1.5 days and its removal from the plasma is relatively late; thus, it is likely to remain high at the time of the test, making it more sensitive for muscle injury determination and diagnosis of rhabdomyolysis [17]. In this study, the SIR group had a higher CPK level and longer hospital stay than the NSIR group. Moreover, the incidence rate is higher in patients with SIR than in those with NSIR despite the shorter exercise duration (less than 1 hour). Given that, unlike other exercises, the spinning classes have fixed start and end times, which are accompanied by some force regardless of the individual’s basic exercise ability. In addition, it is presumed that a competition intensity is stimulated because majority of the patients perform spinning exercises at the same time; thus, muscle damage is easily caused by short exercise duration with a high exercise intensity. Therefore, in the first class, a step-by-step exercise program is recommended, avoiding full intensity spinning. The results showed a higher CPK level and a longer hospital stay in SIR than in NSIR. But these results were not statistically significant and probably due to the small sample size. In general, the spinning classes take a fixed duration, and usually last for 40–60 minutes [8]. Since the study about spinning exercise duration has not been performed, further studies are required to compare the results about the differences of exercise duration.
Studies have shown that CK-MB can be a sensitive indicator of skeletal muscle injury in EIR [18]. In this study, the initial CK-MB level of SIR was significantly higher than that of NSIR, which suggests that muscle injury was more severe in SIR than in NSIR.
The most relevant complication of rhabdomyolysis is AKI due to myoglobin deposits in the renal tubules, leading to direct toxicity, intrarenal vasoconstriction, and decreased glomerular filtration rate [19]. The reported incidence of AKI in patients with rhabdomyolysis ranges from 13% to 50% [1,20], and the overall mortality of AKI is 8% [21]. A study found that EIR had a lower AKI rate than other etiologies [1]. McMahon et al. [22] reported that the rates of renal replacement therapy and in-hospital mortality were lower in EIR than in rhabdomyolysis with other etiologies. One study reported that 1 of 14 SIR cases and 0 of 15 NSIR cases developed AKI [20]. In our study, none of the 23 SIR patients developed AKI, whereas 5 of the 39 NSIR patients developed AKI. This low rate of renal failure in the SIR group is consistent with the studies of Hernández-Contreras et al. [2] and Montero et al. [23]. We found that the SIR group had a higher CPK level, lower Cr level, and lower incidence rate of AKI development than the NSIR group. The reason for this was that most of the young women in the SIR group were healthy individuals without any past medical history, which may have affected the low Cr level and the low incidence of AKI. One of the five patients with AKI in the NSIR group underwent hemodialysis. This 19-year-old woman was admitted due to myalgia and oliguria after performing squatting exercises and was discharged after hemodialysis due to oliguria, hyperkalemia, and generalized edema during hospitalization.
In this study, no prominent acidosis was found in both the SIR and NSIR groups, but the initial pH was lower in the SIR group (p=0.042). Acute metabolic acidosis is another complication of rhabdomyolysis. Acidosis results from the release of intracellular phosphate and sulfate. Sulphur-containing proteins released in large amounts can lead to hydrogen and sulphate loads that overwhelm renal excretory mechanisms. Other causes of acidosis in rhabdomyolysis include lactic acidosis from ischemia and acidosis from uremia [24]. Therefore, the lower pH of patients with SIR in our study may indicate that the muscle injury or ischemia is more severe in SIR than in NSIR; thus, the amount of intracellular sulphate exceeds the renal excretory mechanism.
In our study, the incidence rate is higher in SIR than in NSIR despite the short exercise duration. There are specific guidelines to prevent SIR. First, sufficient amount of time to warmup should be considered. Second, standard education on SIR is also important. Instructors and participants should understand the danger, symptoms, and signs of SIR. Third, exercise should be modified or abstained in the presence of evitable risk factors such as viral diseases. Lastly, sufficient hydration and nutrition support can be effective [4].
This study had several limitations. First, this study was retrospective in nature, was conducted in a single center, and had a small sample. In addition, accurate values could not be compared when the upper limit was exceeded, since the upper limits of CPK and myoglobin level were 15,000 U/L and 1,000 ng/mL, respectively. Elevation of CPK is one of the main serologic criteria defining the disease entity. However, there is no definite level of the CPK increase that could identify clinically relevant EIR [25]. In addition, the bone scan was not performed on many cases in this study. Therefore, prospective large-scale studies should be conducted in the future.
SIR occurs at a higher rate during the first exercise class in women compared to NSIR, and the incidence rate is higher in patients with SIR than in those with NSIR despite the shorter exercise duration (less than 1 hour). Compared with NSIR patients, most patients with SIR complained of thigh pain during admission to the hospital. It is necessary to recognize these risks during spinning exercises and to perform the exercises sequentially and systematically. Moreover, instructors should be aware of the possibility of rhabdomyolysis in spinning exercise classes. Our study has small sample size, so large-scale studies will be needed.
Fig. 1
Study population. CPK: creatine phosphokinase, SIR: spinning-induced rhabdomyolysis, NSIR: non-spinning exercise- induced rhabdomyolysis.
Fig. 2
Comparison of exercise duration and peak CPK level between SIR and NSIR. CPK: peak creatine phosphokinase, SIR: spinning-induced rhabdomyolysis, NSIR: non-spinning exercise-induced rhabdomyolysis.
Table 1
Comparison of clinical factors and outcomes between SIR and NSIR
SIR (n=23) NSIR (n=39) p-value
Sex (female) 18/23 (78.3) 15/39 (38.5) 0.002

Age (years) 28.0 (22.0–30.0) 26.0 (22.0–30.5) 0.907

BMI (kg/m2) 24.40 (21.40–26.40) 22.40 (20.70–24.25) 0.275

First exercise class 14/23 (60.9) 6/39 (15.4) 0.001

Most painful site (thigh) 21/23 (91.3) 17/39 (43.6) 0.001

Duration of exercise (minutes) 60 (50–60) 60 (60–90) 0.011

Duration of exercise (less than 60 minutes) 19/23 (90.5) 22/39 (62.9) 0.024

Time from activity to initial symptom (days) 1.0 (0.5–1.0) 1.0 (0.5–1.0) 0.844

Time from activity to visit (days) 3 (2–4) 2 (1–3) 0.172

Previous activity experience (none) 10/11 (90.9) 9/13 (69.2) 0.327

Past medical history (yes) 2/23 (8.7) 8/39 (20.5) 0.298

Initial symptom 1.000
 Myalgia 21/23 (91.3) 34/39 (87.2)
 Dark urine 1/23 (4.3) 2/39 (5.1)
 Others 1/23 (4.3) 3/39 (7.7)

Chief complaint 0.151
 Myalgia 4/23 (17.4) 13/39 (33.3)
 Dark-urine 19/23 (82.6) 23/39 (59.0)
 Others 0/23 (0) 3/39 (7.7)

Location of initial visit 0.055
 ED 15/23 (65.2) 34/39 (87.2)
 OPD 8/23 (34.8) 5/39 (12.8)

Hospital admission 21/23 (91.3) 33/39 (84.6) 0.523

Length of hospital stay (day) 6.0 (4.5–7.0) 5.0 (3.5–6.0) 0.080

Time from activity to peak CPK (day) 3 (2–4) 2 (1–3) 0.133

Bone scan uptake (thigh) 7/7 (100.0) 13/16 (81.3) 0.526

 Pulmonary edema 0/23 (0) 1/39 (2.6) 1.000
 AKI 0/23 (0) 5/39 (12.8) 0.148
 Hyperkalemia 0/23 (0) 1/39 (2.6) 1.000
 Hemodialysis 0/23 (0) 1/39 (2.6) 1.000

Values are presented as number (%) or median (interquartile range).

SIR: spinning-induced rhabdomyolysis, NSIR: non-spinning exercise-induced rhabdomyolysis, BMI: body mass index, ED: emergency department, OPD: outpatient department, CPK: creatine phosphokinase, AKI: acute kidney injury.

Table 2
Comparison of the laboratory test results between SIR and NSIR
SIR (n=23) NSIR (n=39) p-value
 Peak 15,000.0 (15,000.0–15,000.0) 15,000.0 (14,839.5–15,000.0) 0.359
 Initial 15,000.0 (15,000.0–15,000.0) 15,000.0 (14,839.5–15,000.0) 0.549
 Discharge 3,347.0 (1,750.5–7,005.5) 3,084.0 (2,049.5–6,717.0) 0.901

CKMB (initial, ng/mL) 88.95 (25.30–103.60) 25.65 (10.70–50.85) 0.012

Myoglobin (initial, ng/mL) 1,000 (1,000–1,000) 1,000 (1,000–1,000) 0.155

AST (U/L) 869.0 (632.5–1,250.5) 482.0 (217.5–1,333.5) 0.117

ALT (U/L) 298.0 (154.0–378.0) 180.0 (120.5–338.0) 0.153

BUN (mg/dL) 10.60 (8.00–12.15) 15.30 (11.80–18.55) <0.001

Cr (mg/dL) 0.60 (0.50–0.60) 0.80 (0.60–0.92) 0.001

pH 7.39 (7.37–7.40) 7.42 (7.40–7.43) 0.042

Values are presented as median (interquartile range).

SIR: spinning-induced rhabdomyolysis; NSIR: non-spinning exercise-induced rhabdomyolysis, CPK: creatine phosphokinase, CKMB: creatine kinase-muscle/ brain, AST: aspartate transaminase, ALT: alanine transaminase, BUN: blood urea nitrogen, Cr: creatinine.

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