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HOME > J Korean Soc Traumatol > Volume 17(1); 2004 > Article
Effect of Administ ration of Glutamine and N-Acety l cysteine on Hepatic Antioxidant Mechanisms in Sepsis
Journal of Trauma and Injury 2004;17(1):1-9
DOI: https://doi.org/
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Department of Emergency Medicine, Seoul National University College of Medicine Department of Surgery, Gangnung Asan Hospital, College of Medicine, Ulsan University*, Cheju National University College of Medicine**, and Seoul National University College of Medicine***

Background
Glutathione (GSH) has been known to be an important intracellular antioxidant. The aim of this study was to investigate the effects of the glutamine and N-acetylcysteine (NAC) on lipid peroxidation and antioxidant effect in sepsis model. Methods: All female Sprague-Dawley rats were given an intraperitoneal diethylmaleate (DEM) injection before treatment, and divided into four groups: control group (DEM only), lipopolysaccharide (LPS) treated group (DLPS), LPS with glutamine treated group (DLPG) and LPS with both glutamine and NAC treated group (DLPGC). Animals were killed at 6 and 24 hours after treatment. The histology and the counts of the infiltrative neutrophils, and the levels of malondialdehyde (MDA) and GSH in the liver were measured. Results: While the liver histology in the both DLPG and DLPGC groups showed mild neutrophil infiltration, vacuolization of hepatocytes, and the sinusoidal dilation compared to those of the DLPS group, there was no significant change of the neutrophil counts between the treatment groups. Both the DLPG and DLPGC groups showed decreases in liver MDA level compared to the DLPS group. Although both the DLPG and DLPGC groups demonstrated significant increases in the liver GSH level compared to the DLPS group, there was no significant change between the DLPG and DLPGC groups. Conclusion: This study showed that the administration of the glutamine and NAC in sepsis model revealed an inhibition of the lipid peroxidation and an antioxidant effect through the increase of GSH in the liver.

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