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Journal of Trauma and Injury 2013;26(1):6-13.
Sulforaphane Post-treatment Had No Protective Effects in Paraquat-intoxicated Rats
Gui Sang Jang, Jae Hyuk Lee, Kyuseok Kim, You Hwan Jo, Joong Eui Rhee, Kyoungbun Lee, Chan Jong Park, Chang Woo Kang, Soohoon Lee, Joonghee Kim
1Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonnggi-do, Korea. hyukmd@gmail.com
2Department of Pathology, Seoul National University Hospital, Seoul, Korea.
쥐의 파라쿼트 중독 모델에서 설포라판의 영향
장귀상, 이재혁, 김규석, 조유환, 이중의, 이경분1, 박찬종, 강창우, 이수훈, 김중희
분당서울대학교병원 응급의학과, 1서울대학교병원 병리과
Received: 20 December 2012   • Revised: 18 January 2013   • Accepted: 12 February 2013
Abstract
PURPOSE
Sulforaphane is a naturally-occurring isothiocyanate abundant in broccoli. It has been suggested as a promising antioxidant. In this study, the therapeutic effect of sulforaphane in paraquat intoxication was investigated.
METHODS
Paraquat was administered via the tail vein, after which sulforaphane or a vehicle (4% DMSO) was administered intraperitoneally 15 minutes after paraquat administration. Histological injury, lipid peroxidation, plasma cytokine (IL-6, IL-10), and nitric oxide were measured. In addition, the effect of sulforaphane on survival in paraquat-intoxication was observed.
RESULTS
Regarding histological injury, lipid peroxidation, and plasma cytokine and nitric-oxide response, sulforaphane administration showed no protective effects in paraquat-intoxicated rats. Rather, it increased mortality (log rank p=0.03) and caused lipid peroxidation, as well as plasma cytokine and nitric-oxide production, to be increased.
CONCLUSION
Sulforaphane had no therapeutic effect on paraquat-intoxicated rats; rather, it increased mortality.
Key Words: Paraquat; Sulforaphane; Lipid peroxidation
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