Skip Navigation
Skip to contents

J Trauma Inj : Journal of Trauma and Injury



Page Path
HOME > J Trauma Inj > Volume 26(1); 2013 > Article
Sulforaphane Post-treatment Had No Protective Effects in Paraquat-intoxicated Rats
Gui Sang Jang, Jae Hyuk Lee, Kyuseok Kim, You Hwan Jo, Joong Eui Rhee, Kyoungbun Lee, Chan Jong Park, Chang Woo Kang, Soohoon Lee, Joonghee Kim
Journal of Trauma and Injury 2013;26(1):6-13
  • 5 Download
  • 0 Crossref
  • 0 Scopus
1Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonnggi-do, Korea.
2Department of Pathology, Seoul National University Hospital, Seoul, Korea.
Received: 20 December 2012   • Revised: 18 January 2013   • Accepted: 12 February 2013

Sulforaphane is a naturally-occurring isothiocyanate abundant in broccoli. It has been suggested as a promising antioxidant. In this study, the therapeutic effect of sulforaphane in paraquat intoxication was investigated.
Paraquat was administered via the tail vein, after which sulforaphane or a vehicle (4% DMSO) was administered intraperitoneally 15 minutes after paraquat administration. Histological injury, lipid peroxidation, plasma cytokine (IL-6, IL-10), and nitric oxide were measured. In addition, the effect of sulforaphane on survival in paraquat-intoxication was observed.
Regarding histological injury, lipid peroxidation, and plasma cytokine and nitric-oxide response, sulforaphane administration showed no protective effects in paraquat-intoxicated rats. Rather, it increased mortality (log rank p=0.03) and caused lipid peroxidation, as well as plasma cytokine and nitric-oxide production, to be increased.
Sulforaphane had no therapeutic effect on paraquat-intoxicated rats; rather, it increased mortality.

Comments on this article

DB Error: no such table